There is a five-fold increase in ectopic (tubal) pregnancies for DES daughters. This is a pregnancy that implants in the tube as opposed to the uterus. All DES daughters should be considered at risk for an ectopic pregnancy. Early confirmation of pregnancy and vigilance in treatment is essential, since an undiagnosed tubal pregnancy can rupture and be life-threatening.

     A "T-shape" or other uterine abnormality may inhibit or prevent implantation of a fertilized egg, resulting in infertility or miscarriage. A small uterus or one with a thin or irregular lining may prohibit the uterus from undergoing the extensive expansion necessary during pregnancy to accommodate the growing fetus. This in turn may result in the increased preterm labor experienced among DES daughters. A small or deformed cervix may become "incompetent" meaning that it dilates prematurely, often resulting in early rupture of the membranes and a precipitous delivery of a very premature baby. DES daughters have a two- to three-fold increased risk of miscarriage and a four- to five-fold increased risk in premature deliveries. For these reasons, you should seek out obstetrical care as soon as you suspect you are pregnant, if not before. Your physician should be either a perinatologist or an obstetrician familiar with high-risk pregnancies. You will likely to need to see your doctor on a more frequent basis during your pregnancy and special tests or procedures may be necessary. If your doctor diagnoses an "incompetent cervix", he may recommend that your cervix be stitched shut during the pregnancy. This may help prevent the cervix from dilating too early. You may also be advised to stay off your feet as much as possible, or even to maintain bedrest.